Cytokeratin 81/86 Antibodies

Target Information

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.

Synonyms

ghHb1; ghHKb1; hair keratin K2.11; Hair keratin K2.9; hard keratin, type II, 1; hard keratin, type II, 6; Hb1; Hb-1; HB6; hHAKB2-1; K81; K86; keratin 81; keratin 81, type II; keratin 86; keratin 86, type II; keratin protein HB6; keratin, hair, basic, 1; keratin, hair, basic, 6 (monilethrix); keratin, type II cuticular Hb1; Keratin, type II cuticular Hb6; keratin-81; Keratin-86; KRT81; KRT86; KRTHB1; KRTHB6; Metastatic lymph node 137 gene protein; MLN 137; MLN137; MNX; Type II hair keratin Hb1; type II hair keratin Hb6; Type-II keratin Kb21; type-II keratin Kb26